賈不妙因此綁架了小美人，並將她帶到巴黎。老爹與小笨蛋被迫回到人類的世界，請人類好友協助拯救小美人！一直認為自己跟其他小精靈不大一樣的小美人，會不會變成小調皮同一國的？

In this sequel to the hybrid live action/animated family blockbuster comedy The Smurfs, the evil wizard Gargamel creates a couple of mischievous Smurf-like creatures called the Naughties that he hopes will let him harness the all-powerful, magical Smurf-essence. But when he discovers that only a real Smurf can give him what he wants, and only a secret spell that Smurfette knows can turn the Naughties into real Smurfs, Gargamel kidnaps Smurfette and brings her to Paris, where he has been winning the adoration of millions as the world1s greatest sorcerer. It's up to Papa, Clumsy, Grouchy, and Vanity to return to our world, reunite with their human friends Patrick and Grace Winslow, and rescue her! Will Smurfette, who has always felt different from the other Smurfs, find a new connection with the Naughties Vexy and Hackus ¬ or will the Smurfs convince her that their love for her is True Blue? Returning cast includes Neil Patrick Harris, Jayma Mays, Sofia Vegara, Hank Azaria as Gargamel and Katy Perry as Smurfette. Brendan Gleeson joins the cast as Victor Winslow.

Cast:
Neil Patrick Harris (Patrick Winslow)
Brendan Gleeson (Victor Doyle)
Jayma Mays (Grace Winslow)
Sofia Vergara (Odile)
Hank Azaria (Gargamel)

Smurfs:
Katy Perry (Smurfette)
Jonathan Winters (Papa)
Christina Ricci (Vexy)